A +8 (-->CT) mutation within the 5' untranslated region of beta-globin down-regulates the mRNA transcription.

doi:10.1080/03630260701798375

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A +8 (-->CT) mutation within the 5' untranslated region of beta-globin down-regulates the mRNA transcription.

Hemoglobin - 1 Jan 2008

Van de Water Neil, Tan Tina, Chan George, Cole Nyree, Browett Peter

Abstract excerpt

The 5' untranslated region (5'UTR) of beta-globin has been well characterized and is often used as a model for eukaryotic transcription/translation, but there are still questions regarding the mechanism of translational control. Mutations affecting the Cap site at + 1 and at positions +10, +22, +33 and +40-43 have been described, and it is thought that the initiator element required for transcription stretches...

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A +8 (-->CT) mutation within the 5' untranslated region of beta-globin down-regulates the mRNA transcription.

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A +8 (-->CT) mutation within the 5' untranslated region of beta-globin down-regulates the mRNA transcription.

Abstract excerpt

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