Article
Molecular characterization of a variant Ph1 translocation t(9;22;11) (q34;q11;q13) in chronic myelogenous leukemia (CML) reveals the translocation of the 3'-part of BCR gene to the chromosome band 11q13.
Oncogene - 1 Dec 1993
Koduru P R, Goh J C, Pergolizzi R G, Lichtman S M, Broome J D
Abstract excerpt
We performed cloning and sequence analysis of translocation junctions at 11q- and 22q- (Ph1) chromosomes and the corresponding germline DNAs of a variant Ph1-positive CML with t(9;22;11)(q34;q11;q13). Southern blot analysis using probes for different regions of bcr mapped the translocation break...
Topics
- Base Sequence
- Blotting, Northern
- Blotting, Southern
- Chromosome Banding
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 22
- Chromosomes, Human, Pair 9
- Chronic Disease
- Cloning, Molecular
- DNA, Neoplasm
- Exons
- Genetic Variation
- Glutathione Transferase