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Article

Cryptic BCR-ABL fusion gene as variant rearrangement in chronic myeloid leukemia: molecular cytogenetic characterization and influence on TKIs therapy.

Oncotarget - 2 May 2017

Luatti Simona, Baldazzi Carmen, Marzocchi Giulia, Ameli Gaia, Bochicchio Maria Teresa, Soverini Simona, Castagnetti Fausto, Tiribelli Mario, Gugliotta Gabriele, Martinelli Giovanni, Baccarani Michele, Cavo Michele, Rosti Gianantonio, Testoni Nicoletta

Abstract excerpt

At diagnosis, about 5% of Chronic Myeloid Leukemia (CML) patients lacks Philadelphia chromosome (Ph), despite the presence of the BCR/ABL rearrangement. Two mechanisms have been proposed about the occurrence of this rearrangement: the first one is a cryptic insertion between chromosomes 9 and 22; the second one involves two sequential translocations: a classic t(9;22) followed by a reverse translocation, which...

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Share to Antineoplastic Combined Chemotherapy Protocols
Share to Fusion Proteins, bcr-abl

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

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Share to Protein Kinase Inhibitors

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Source

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Identifiers

PMID: 28404889
DOI: 10.18632/oncotarget.15369
PMCID: PMC5444712

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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