Article
Molecular cytogenetic characterization of variant Philadelphia translocations in chronic myeloid leukemia: genesis and deletion of derivative chromosome 9.
Cancer genetics and cytogenetics - 1 Oct 2009
Bennour Ayda, Sennana Halima, Laatiri Mohamed Adnène, Elloumi Moez, Khelif Abderrahim, Saad Ali
Abstract excerpt
The mechanisms for the formation of variant Philadelphia (Ph) translocations that occur in 5-10% of patients with chronic myeloid leukemia (CML) are not fully characterized. Studies on the prognosis of these variant translocations have yielded conflicting results, especially regarding imatinib outcome and the status of deletions on the derivative chromosome 9. To shed light on these controversial subjects, we...
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