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Article

The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene.

Oncogene - 3 Nov 2005

Bousquet Marina, Quelen Cathy, De Mas Véronique, Duchayne Eliane, Roquefeuil Blandine, Delsol Georges, Laurent Guy, Dastugue Nicole, Brousset Pierre

Abstract excerpt

Several tyrosine kinase genes are involved in chromosomal translocations in chronic myeloproliferative disorders, but there are still uncharacterized translocations in some cases. We report two such cases corresponding to atypical chronic myeloid leukaemia with a t(8;9)(p22;p24) translocation. By fluorescence in situ hybridisation (FISH) on the corresponding metaphases with a bacterial artificial chromosome probe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16091753
DOI: 10.1038/sj.onc.1208850

Genes

JAK2
PCM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene.PMID 16091753Read ↗

The t(8;9)(p22;p24) Is a Recurrent Abnormality in Chronic and Acute Leukemia that Fuses <i>PCM1</i> to <i>JAK2</i>Semantic proximity Read ↗

PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocationSemantic proximity Read ↗

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A <i>BCR–JAK2</i> fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemiaSemantic proximity Read ↗

A variant t(8;10;21) in a patient with pathological features mimicking atypical chronic myeloid leukemia.Semantic proximity Read ↗

Hematologic malignancies with PCM1-JAK2 gene fusion share characteristics with myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1.Semantic proximity Read ↗

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Double jeopardy from a single translocation: deletions of the derivative chromosome 9 in chronic myeloid leukemiaSemantic proximity Read ↗

Novel SSBP2-JAK2 fusion gene resulting from a t(5;9)(q14.1;p24.1) in pre-B acute lymphocytic leukemia.Semantic proximity Read ↗

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