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Article

Cytogenetic and Molecular Genetic Evolution of Chronic Myeloid Leukemia

1 Jan 2002

Abstract excerpt

Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR/ABL gene fusion on the derivative chromosome 22 called the Philadelphia (Ph) chromosome. In 2-10% of the cases, this chimeric gene is generated by variant rearrangements, involving 9q34, 22q11, and one or several other genomic regions. All chromosomes have been described...

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PMID: 11919388
DOI: 10.1159/000046636

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