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Article

Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit.

Nature - 25 Nov 1993

Gordon C, McGurk G, Dillon P, Rosen C, Hastie N D

Abstract excerpt

We have isolated a mutant, mts2, in the fission yeast Schizosaccharomyces pombe which is defective in chromosome segregation. The predicted amino-acid sequence of the cloned mts2+ gene product is 75% identical to the S4 subunit of the human 26S ATP/ubiquitin-dependent protease. The human S4 subunit complementary DNA expressed from an S. pombe expression plasmid can rescue an S. pombe mts2 gene disruption. Both...

Topics

Amino Acid Sequence
Endopeptidases
Genes, Fungal
Genetic Complementation Test
HeLa Cells
Humans
Mitosis
Molecular Sequence Data
Mutation
Schizosaccharomyces
Schizosaccharomyces pombe Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Homology, Amino Acid

Temperature

Source

Identifiers

PMID: 8247131
DOI: 10.1038/366355a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8247131-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit.PMID 8247131Read ↗

Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2.Semantic proximity Read ↗

Characteristics of 26 S proteases from fission yeast mutants, which arrest in mitosis.Semantic proximity Read ↗

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The 26S proteasome of the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

A screen for genes involved in the anaphase proteolytic pathway identifies tsm1(+), a novel Schizosaccharomyces pombe gene important for microtubule integrity.Semantic proximity Read ↗

Mms1-Mms22 complex protects genome integrity in Schizosaccharomyces pombe.Semantic proximity Read ↗

Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.Semantic proximity Read ↗

A conditional lethal mutant in the fission yeast 26 S protease subunit mts3+ is defective in metaphase to anaphase transition.Semantic proximity Read ↗

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Gene disruption in Schizosaccharomyces pombe using a temperature-sensitive Ura4p.Semantic proximity Read ↗

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