Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit.

Nature - 25 Nov 1993

Gordon C, McGurk G, Dillon P, Rosen C, Hastie N D

Abstract excerpt

We have isolated a mutant, mts2, in the fission yeast Schizosaccharomyces pombe which is defective in chromosome segregation. The predicted amino-acid sequence of the cloned mts2+ gene product is 75% identical to the S4 subunit of the human 26S ATP/ubiquitin-dependent protease. The human S4 subunit complementary DNA expressed from an S. pombe expression plasmid can rescue an S. pombe mts2 gene disruption. Both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Genes, Fungal
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Molecular Sequence Data

Share to Mutation

Share to Sequence Homology, Amino Acid

Share to Temperature

Source

Identifiers

PMID: 8247131
DOI: 10.1038/366355a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit.PMID 8247131Read ↗

Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2.Semantic proximity Read ↗

Characteristics of 26 S proteases from fission yeast mutants, which arrest in mitosis.Semantic proximity Read ↗

S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase.Semantic proximity Read ↗

The 26S proteasome of the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

A screen for genes involved in the anaphase proteolytic pathway identifies tsm1(+), a novel Schizosaccharomyces pombe gene important for microtubule integrity.Semantic proximity Read ↗

Mms1-Mms22 complex protects genome integrity in Schizosaccharomyces pombe.Semantic proximity Read ↗

Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.Semantic proximity Read ↗

A conditional lethal mutant in the fission yeast 26 S protease subunit mts3+ is defective in metaphase to anaphase transition.Semantic proximity Read ↗

Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast.Semantic proximity Read ↗

Gene disruption in Schizosaccharomyces pombe using a temperature-sensitive Ura4p.Semantic proximity Read ↗

Role of fission yeast primase catalytic subunit in the replication checkpoint.Semantic proximity Read ↗

Genetics of lagging strand DNA synthesis and maturation in fission yeast: suppression analysis links the Dna2-Cdc24 complex to DNA polymerase delta.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.