Article
Mts4, a non-ATPase subunit of the 26 S protease in fission yeast is essential for mitosis and interacts directly with the ATPase subunit Mts2.
The Journal of biological chemistry - 10 Oct 1997
Wilkinson C R, Wallace M, Seeger M, Dubiel W, Gordon C
Abstract excerpt
We have isolated a fission yeast gene, mts4(+), by complementation of a temperature-sensitive mutation and show that it encodes subunit 2 (S2) of the 19 S regulatory complex of the 26 S protease. mts4(+) is an essential gene, and we show that loss of this subunit causes cells to arrest in metapha...
Topics
- Adenosine Triphosphatases
- Alleles
- Amino Acid Sequence
- Carrier Proteins
- Cell Cycle Proteins
- Cell Survival
- Cyclin-Dependent Kinase Inhibitor p15
- Cyclin-Dependent Kinase Inhibitor p16
- Cysteine Endopeptidases
- Endopeptidases
- Fungal Proteins
- Humans
- Intracellular Signaling Peptides and Proteins
- Mitosis