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Article

A screen for genes involved in the anaphase proteolytic pathway identifies tsm1(+), a novel Schizosaccharomyces pombe gene important for microtubule integrity.

Genetics - 1 Jul 1998

Grishchuk E L, Howe J L, McIntosh J R

Abstract excerpt

The growth of several mitotic mutants of Schizosaccharomyces pombe, including nuc2-663, is inhibited by the protease inhibitor N-Tosyl-L-Phenylalanine Chloromethyl Ketone (TPCK). Because nuc2(+) encodes a presumptive component of the Anaphase Promoting Complex, which is required for the ubiquitin-dependent proteolysis of certain proteins during exit from mitosis, we have used sensitivity to TPCK as a criterion by...

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Identifiers

PMID: 9649518
DOI: 10.1093/genetics/149.3.1251
PMCID: PMC1460230

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