Article
A screen for genes involved in the anaphase proteolytic pathway identifies tsm1(+), a novel Schizosaccharomyces pombe gene important for microtubule integrity.
Genetics - 1 Jul 1998
Grishchuk E L, Howe J L, McIntosh J R
Abstract excerpt
The growth of several mitotic mutants of Schizosaccharomyces pombe, including nuc2-663, is inhibited by the protease inhibitor N-Tosyl-L-Phenylalanine Chloromethyl Ketone (TPCK). Because nuc2(+) encodes a presumptive component of the Anaphase Promoting Complex, which is required for the ubiquitin...
Topics
- Anaphase
- Cell Cycle
- DNA-Binding Proteins
- Fungal Proteins
- Genetic Testing
- Genotype
- Microtubules
- Mitosis
- Models, Genetic
- Mutagenesis
- Saccharomyces cerevisiae Proteins
- Schizosaccharomyces
- TATA-Binding Protein Associated Factors
- Tosylphenylalanyl Chloromethyl Ketone
- Transcription Factor TFIID
- Transcription Factors