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Article

In vivo species specificity of DNA polymerase alpha.

Molecular & general genetics : MGG - 1 Nov 1993

Francesconi S, Copeland W C, Wang T S

Abstract excerpt

The DNA polymerase alpha enzymes from human, and budding (Saccharomyces cerevisiae) and fission yeast (Schizosaccharomyces pombe) are homologous proteins involved in initiation and replication of chromosomal DNA. Sequence comparison of human DNA polymerase alpha with that of S. cerevisiae and S. pombe shows overall levels of amino acid sequence identity of 32% and 34%, respectively. We report here that, despite...

Topics

Alleles
Amino Acid Sequence
Conserved Sequence
DNA Polymerase I
DNA Polymerase II
Fungal Proteins
Genetic Complementation Test
Humans
Recombinant Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Schizosaccharomyces

Sequence Homology, Amino Acid

Species Specificity

Temperature

Source

Identifiers

PMID: 8246900
DOI: 10.1007/BF00284700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8246900-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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