Dominant negative rat DNA polymerase beta mutants interfere with base excision repair in Saccharomyces cerevisiae.

doi:10.1128/jb.178.3.656-661.1996

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Article

Dominant negative rat DNA polymerase beta mutants interfere with base excision repair in Saccharomyces cerevisiae.

Journal of bacteriology - 1 Feb 1996

Clairmont C A, Sweasy J B

Abstract excerpt

DNA polymerase beta is one of the smallest known eukaryotic DNA polymerases. This polymerase has been very well characterized in vitro, but its functional role in vivo has yet to be determined. Using a novel competition assay in Escherichia coli, we isolated two DNA polymerase beta dominant negat...

Topics

Animals
DNA Polymerase I
DNA Repair
Escherichia coli
Methyl Methanesulfonate
Mutation
Rats
Saccharomyces cerevisiae
Ultraviolet Rays

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