Article
Mapping and mutation of the conserved DNA polymerase interaction motif (DPIM) located in the C-terminal domain of fission yeast DNA polymerase delta subunit Cdc27.
BMC molecular biology - 3 Dec 2004
Gray Fiona C, Pohler J Richard G, Warbrick Emma, MacNeill Stuart A
Abstract excerpt
BACKGROUND: DNA polymerases alpha and delta play essential roles in the replication of chromosomal DNA in eukaryotic cells. DNA polymerase alpha (Pol alpha)-primase is required to prime synthesis of the leading strand and each Okazaki fragment on the lagging strand, whereas DNA polymerase delta (Pol delta) is required for the elongation stages of replication, a function it appears capable of performing on both...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.