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Article

TP53 and MDM2 genetic alterations in non-small cell lung cancer: Evaluating their prognostic and predictive value.

Critical reviews in oncology/hematology - 1 Mar 2016

Deben Christophe, Deschoolmeester Vanessa, Lardon Filip, Rolfo Christian, Pauwels Patrick

Abstract excerpt

The p53 pathway has been extensively studied for its role in carcinogenesis. Disruption of the pathway occurs in more than half of all cancers, often leading to a worse prognosis for the patient. In recent years several compounds have been successfully developed to target and restore the p53 pathway, either by blocking the MDM2-p53 interaction, restoring wild type conformation of mutant p53, or exploiting the...

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Source

Identifiers

PMID: 26689115
DOI: 10.1016/j.critrevonc.2015.11.019

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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