Immunohistochemical expression and mutation study of Prohibitin gene in Indian female breast cancer cases.

doi:10.1007/s12032-013-0614-8

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Article

Immunohistochemical expression and mutation study of Prohibitin gene in Indian female breast cancer cases.

Medical oncology (Northwood, London, England) - 1 Jan 2013

Najm Mohammad Zeeshan, Zaidi Shuaib, Siddiqui Waseem Ahmad, Husain Syed Akhtar

Abstract excerpt

Prohibitin (PHB1) is highly conserved and ubiquitously expressed protein. It is mapped to the chromosome 17q12-q21 locus, a region that has been reported to be genetically linked to early onset of breast cancer. Therefore, we carried out the population-based study in a total of 105 Indian female breast cancer cases and analyzed mutation(s) on exon 4 and the introns flanking it. Importantly, it has been found that...

Topics

Biomarkers, Tumor
Breast Neoplasms
Exons
Female
Genes, p53
Humans
Immunohistochemistry
India
Introns
Middle Aged
Mutation
Prohibitins
Repressor Proteins

Source

Open in PubMed

Identifiers

PMID: 23715748
DOI: 10.1007/s12032-013-0614-8

Genes

PHB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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