Article
Prohibitin expression deregulation in gastric cancer is associated with the 3' untranslated region 1630 C>T polymorphism and copy number variation.
PloS one - 1 Jan 2014
Leal Mariana Ferreira, Cirilo Priscila Daniele Ramos, Mazzotti Tatiane Katsue Furuya, Calcagno Danielle Queiroz, Wisnieski Fernanda, Demachki Samia, Martinez Margarita Cortes, Assumpção Paulo Pimentel, Chammas Roger, Burbano Rommel Rodríguez, Smith Marília Cardoso
Abstract excerpt
PHB is a reported oncogene and tumor suppressor in gastric cancer. Here, we evaluated whether the PHB copy number and the rs6917 polymorphism affect its expression in gastric cancer. Down-regulation and up-regulation of PHB were observed in the evaluated tumors. Reduced expression was associated with tumor dedifferentiation and cancer initiation. The T allele of the rs6917 polymorphism was associated with reduced...
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