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Article

The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation.

Breast cancer research and treatment - 1 Jul 2007

Jakubowska Anna, Gronwald Jacek, Górski Bohdan, Huzarski Tomasz, Byrski Tomasz, Benner Axel, Lubiński Jan, Scott Rodney J, Hamann Ute

Abstract excerpt

The variable penetrance of breast cancer in BRCA1 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. The C to T transition in the 3' untranslated region of the prohibitin (PHB) gene alters mRNA function and has been shown to be associated with an increased breast cancer risk among young North-American women who have one first-degree relative with breast cancer. To...

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Identifiers

PMID: 17004108
DOI: 10.1007/s10549-006-9389-3

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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The 3' untranslated region C > T polymorphism of prohibitin is a breast cancer risk modifier in Polish women carrying a BRCA1 mutation.PMID 17004108Read ↗

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Immunohistochemical expression and mutation study of Prohibitin gene in Indian female breast cancer cases.Semantic proximity Read ↗

Association of 758 G/A polymorphism of 3'untranslated region of prohibitin with risk of gastric cancer.Semantic proximity Read ↗

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Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study.Semantic proximity Read ↗

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