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Article

Genetic evidence for functional interactions between actin noncomplementing (Anc) gene products and actin cytoskeletal proteins in Saccharomyces cerevisiae.

Genetics - 1 Oct 1993

Vinh D B, Welch M D, Corsi A K, Wertman K F, Drubin D G

Abstract excerpt

We describe here genetic interactions between mutant alleles of Actin-NonComplementing (ANC) genes and actin (ACT1) or actin-binding protein (SAC6, ABP1, TPM1) genes. The anc mutations were found to exhibit allele-specific noncomplementing interactions with different act1 mutations. In addition, mutant alleles of four ANC genes (ANC1, ANC2, ANC3 and ANC4) were tested for interactions with null alleles of...

Topics

Actins
Alleles
Genes, Fungal
Genetic Complementation Test
Genotype
Heterozygote
Microfilament Proteins
Plasmids
Saccharomyces cerevisiae
Transformation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8243993
DOI: 10.1093/genetics/135.2.275
PMCID: PMC1205634

Genes

TPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8243993-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Genetic evidence for functional interactions between actin noncomplementing (Anc) gene products and actin cytoskeletal proteins in Saccharomyces cerevisiae.PMID 8243993Read ↗

Screens for extragenic mutations that fail to complement act1 alleles identify genes that are important for actin function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Unexpected combinations of null mutations in genes encoding the actin cytoskeleton are lethal in yeast.Semantic proximity Read ↗

Anc1, a protein associated with multiple transcription complexes, is involved in postreplication repair pathway in S. cerevisiae.Semantic proximity Read ↗

A nuclear protein with sequence similarity to proteins implicated in human acute leukemias is important for cellular morphogenesis and actin cytoskeletal function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Actin mutations that show suppression with fimbrin mutations identify a likely fimbrin-binding site on actin.Semantic proximity Read ↗

A yeast TCP-1-like protein is required for actin function in vivo.Semantic proximity Read ↗

Mapping actin surfaces required for functional interactions in vivo.Semantic proximity Read ↗

Generation of an isogenic collection of yeast actin mutants and identification of three interrelated phenotypes.Semantic proximity Read ↗

Suppressor analysis of fimbrin (Sac6p) overexpression in yeast.Semantic proximity Read ↗

Mutations that enhance the cap2 null mutant phenotype in Saccharomyces cerevisiae affect the actin cytoskeleton, morphogenesis and pattern of growth.Semantic proximity Read ↗

The Saccharomyces cerevisiae gene CDC40/PRP17 controls cell cycle progression through splicing of the ANC1 gene.Semantic proximity Read ↗

Allele-specific suppression by formation of new protein-protein interactions in yeast.Semantic proximity Read ↗

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