A nuclear protein with sequence similarity to proteins implicated in human acute leukemias is important for cellular morphogenesis and actin cytoskeletal function in Saccharomyces cerevisiae.

doi:10.1091/mbc.5.6.617

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Article

A nuclear protein with sequence similarity to proteins implicated in human acute leukemias is important for cellular morphogenesis and actin cytoskeletal function in Saccharomyces cerevisiae.

Molecular biology of the cell - 1 Jun 1994

Welch M D, Drubin D G

Abstract excerpt

The cellular functions of the product of the Saccharomyces cerevisiae ANC1 (actin non-complementing) gene were investigated. ANC1 was previously identified in a screen for mutations that enhance the defect caused by a mutation in the actin gene. Here, we show that anc1-1 and anc1 delta 1::HIS3 (gene deletion) mutants exhibit a novel combination of defects in the organization of the actin cytoskeleton and the...

Topics

Actins
Amino Acid Sequence
Base Sequence
Cell Polarity
Chromosome Mapping
Cytoskeleton
DNA Primers
Fungal Proteins
Genes, Fungal
Genes, Lethal
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leukemia

Mating Factor

Molecular Sequence Data

Mutation

Neoplasm Proteins

Nuclear Proteins

Peptides

Source

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Identifiers

PMID: 7949419
DOI: 10.1091/mbc.5.6.617
PMCID: PMC301078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7949419-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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