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Article

Suppressor analysis of fimbrin (Sac6p) overexpression in yeast.

Genetics - 1 Apr 1999

Sandrock T M, Brower S M, Toenjes K A, Adams A E

Abstract excerpt

Yeast fimbrin (Sac6p) is an actin filament-bundling protein that is lethal when overexpressed. To identify the basis for this lethality, we sought mutations that can suppress it. A total of 1326 suppressor mutations were isolated and analyzed. As the vast majority of mutations were expected to simply decrease the expression of Sac6p to tolerable levels, a rapid screen was devised to eliminate these mutations. A...

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Identifiers

PMID: 10101157
DOI: 10.1093/genetics/151.4.1287
PMCID: PMC1460546

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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