Article
Allele-specific suppression by formation of new protein-protein interactions in yeast.
Genetics - 1 Dec 1997
Sandrock T M, O'Dell J L, Adams A E
Abstract excerpt
Yeast fimbrin is encoded by the SAC6 gene, mutations of which suppress temperature-sensitive mutations in the actin gene (ACT1). To examine the mechanism of suppression, we have conducted a biochemical analysis of the interaction between various combinations of wild-type and mutant actin and Sac6 proteins. Previously, we showed that actin mutations that are suppressed by sac6 mutations encode proteins with a...
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