Article
Remapping the insulin gene/IDDM2 locus in type 1 diabetes.
Diabetes - 1 Jul 2004
Barratt Bryan J, Payne Felicity, Lowe Chris E, Hermann Robert, Healy Barry C, Harold Denise, Concannon Patrick, Gharani Neda, McCarthy Mark I, Olavesen Mark G, McCormack Rose, Guja Cristian, Ionescu-Tîrgovişte Constantin, Undlien Dag E, Rønningen Kjersti S, Gillespie Kathleen M, Tuomilehto-Wolf Eva, Tuomilehto Jaakko, Bennett Simon T, Clayton David G, Cordell Heather J, Todd John A
Abstract excerpt
Type 1 diabetes susceptibility at the IDDM2 locus was previously mapped to a variable number tandem repeat (VNTR) 5' of the insulin gene (INS). However, the observation of associated markers outside a 4.1-kb interval, previously considered to define the limits of IDDM2 association, raised the possibility that the VNTR association might result from linkage disequilibrium (LD) with an unknown polymorphism. We...
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