Insulin promoter in human pancreatic β cells contacts diabetes susceptibility loci and regulates genes affecting insulin metabolism

Abstract excerpt

Significance We show that in a human pancreatic β cell line the human insulin gene promoter on chromosome 11 physically contacts sites on other chromosomes. Many of these contacted sites contain type 1 or type 2 diabetes susceptibility loci. We find that insulin gene expression can affect expression of contacted genes on other chromosomes. Some of these genes, in turn, regulate insulin secretion. These results...

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• Share to Genomics and Chromatin Dynamics
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