Article
Multiple DNA variant association analysis: application to the insulin gene region in type I diabetes.
American journal of human genetics - 1 Dec 1994
Julier C, Lucassen A, Villedieu P, Delepine M, Levy-Marchal C, Danzé P M, Bianchi F, Boitard C, Froguel P, Bell J
Abstract excerpt
Association and linkage studies have shown that at least one of the genetic factors involved in susceptibility to insulin-dependent diabetes mellitus (IDDM) is contained within a 4.1-kb region of the insulin gene. Sequence analysis has led to the identification of 10 DNA variants in this region that are associated with increased risk for IDDM. These variants are in strong linkage disequilibrium with each other,...
Topics
- Diabetes Mellitus, Type 1
- Disease Susceptibility
- France
- Genetic Variation
- Humans
- Insulin
- Molecular Epidemiology