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Article

A rapid screening method to detect nonsense and frameshift mutations: identification of disease-causing APC alleles.

Cancer research - 1 Dec 1993

Varesco L, Groden J, Spirio L, Robertson M, Weiss R, Gismondi V, Ferrara G B, White R

Abstract excerpt

A functional screen for nonsense and frameshift mutations has been devised that allows genes of interest to be scanned in segments. This assay is based on the cloning of these segments in-frame with a colorimetric marker gene (lacZ) followed by screening for the level of functional activity from the marker polypeptide (beta-galactosidase). Individuals at risk for any one of a number of genetic diseases, in...

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Identifiers

PMID: 8242605

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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