Article
DHPLC analysis of adenomatous polyposis coli (APC) mutations using ready-to-use APC plates: simple detection of multiple base pair deletion mutations.
Genetic testing - 1 Jun 2008
Kim Il-Jin, Kim Kun, Kang Hio Chung, Jang Sang-Geun, Park Jae-Gahb
Abstract excerpt
The adenomatous polyposis coli (APC), which is the susceptible gene for familial adenomatous polyposis (FAP) and sporadic colorectal cancer, spans 15 exons. The open reading frame of APC is 8529 bp, which encodes 2843 amino acids. Conventional genetic screening involves extensive time as well as...
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