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Article

Development of a Premature Stop Codon-detection method based on a bacterial two-hybrid system.

BMC biotechnology - 2 Sept 2006

Real Sebastián M, Marzese Diego M, Gomez Laura C, Mayorga Luis S, Roqué María

Abstract excerpt

BACKGROUND: The detection of Premature Stop Codons (PSCs) in human genes is very useful for the genetic diagnosis of different hereditary cancers, e.g. Familial Breast Cancer and Hereditary Non-Polyposis Colorectal Cancer (HNPCC). The products of these PSCs are truncated proteins, detectable in vitro by the Protein Truncation Test and in vivo by using the living translation machinery of yeast or bacteria. These...

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Identifiers

PMID: 16948859
DOI: 10.1186/1472-6750-6-38
PMCID: PMC1569827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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