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Article

Truncated adenomatous polyposis coli (APC) tumour suppressor protein can undergo tyrosine phosphorylation.

European journal of cancer (Oxford, England : 1990) - 1 Mar 2000

Norris A L, Clissold P M, Askham J M, Morrison E E, Moncur P, McCall S H, Coletta P L, Meredith D M, Markham A F

Abstract excerpt

Numerous mutations in the adenomatous polyposis coli (APC) gene have been described in colorectal cancer. The vast majority introduce nonsense codons leading to the production of truncated N-terminal APC fragments. Mutations occurring before APC codon 158, have been associated with an attenuated form of familial adenomatous polyposis whereas those occurring at codon 168 or beyond lead to the characteristic form...

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Identifiers

PMID: 10717531
DOI: 10.1016/s0959-8049(99)00305-6

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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