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Article

The gene for spinal cerebellar ataxia 1 (SCA1) is flanked by two closely linked highly polymorphic microsatellite loci.

Human molecular genetics - 1 Sept 1993

Jodice C, Frontali M, Persichetti F, Novelletto A, Pandolfo M, Spadaro M, Giunti P, Schinaia G, Lulli P, Malaspina P

Abstract excerpt

The gene for one form of autosomal dominant spinal cerebellar ataxia (SCA1), is mapped by linkage to chromosome 6p, very close to the microsatellite locus D6S89. Eight large Italian kindreds segregating SCA1, as defined by very close linkage to D6S89, were genotyped with five microsatellite markers linked closely to D6S89, all mapping within a 6 cM interval on 6p. Multipoint linkage analysis and haplotypes from...

Topics

Alleles
Chromosome Mapping
Chromosomes, Human, Pair 6
DNA, Satellite
Female
Genes, Dominant
Genetic Linkage
Genetic Markers
Haplotypes
Humans
Italy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Linkage Disequilibrium

Male

Pedigree

Polymorphism, Genetic

Spinocerebellar Degenerations

Source

Identifiers

PMID: 8242061
DOI: 10.1093/hmg/2.9.1383

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8242061-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The gene for spinal cerebellar ataxia 1 (SCA1) is flanked by two closely linked highly polymorphic microsatellite loci.PMID 8242061Read ↗

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