Article
The gene for autosomal dominant spinocerebellar ataxia (SCA1) maps telomeric to the HLA complex and is closely linked to the D6S89 locus in three large kindreds.
American journal of human genetics - 1 Jul 1991
Zoghbi H Y, Jodice C, Sandkuijl L A, Kwiatkowski T J, McCall A E, Huntoon S A, Lulli P, Spadaro M, Litt M, Cann H M
Abstract excerpt
We studied three large kindreds with the HLA-linked form of spinocerebellar ataxia (SCA1) in order to localize the SCA1 locus on the short arm of chromosome 6 (6p). Two loci containing highly informative dinucleotide repeat sequences were used for linkage analysis. These two loci are D6S89, which...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Human, Pair 6
- Female
- Genes, Dominant
- Genetic Linkage
- HLA-A Antigens
- HLA-B Antigens
- Humans
- Male
- Polymerase Chain Reaction
- Spinocerebellar Degenerations