Neural tube defects without neural crest defects in splotch mice.

Abstract excerpt

Homozygous Splotch mutant mice (Sp/Sp) die on day 14 of gestation with neural tube defects, curly tail, and malformations of neural crest derivatives. Sp1H mice, which have a radiation-induced allele of Splotch with a similar phenotype, were used for this study. The neural tube defects are always located in the lumbosacral region and in 50% of the cases also in the region of the hindbrain. In this report, rare...

Topics

• Abnormalities, Multiple
• Animals
• Disease Models, Animal
• Dosage Compensation, Genetic
• Heterozygote
• Mice
• Mice, Inbred C57BL
• Mice, Inbred Strains
• Mutation
• Neural Crest
• Neural Tube Defects
• Tail