Lack of relationship between glibenclamide metabolism and debrisoquine or mephenytoin hydroxylation phenotypes.

doi:10.1111/j.1365-2125.1990.tb03800.x

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Article

Lack of relationship between glibenclamide metabolism and debrisoquine or mephenytoin hydroxylation phenotypes.

British journal of clinical pharmacology - 1 Sept 1990

Dahl-Puustinen M L, Alm C, Bertilsson L, Christenson I, Ostman J, Thunberg E, Wikström I

Abstract excerpt

The pharmacokinetics of a single oral dose of 1.75 mg glibenclamide were studied in 15 healthy Caucasians including five poor metabolisers of debrisoquine and five poor metabolisers of S-mephenytoin. Plasma glibenclamide concentrations and the urinary concentrations of trans-4- and cis-3-hydroxyg...

Topics

Adult
Debrisoquin
Female
Glyburide
Humans
Hydroxylation
Male
Mephenytoin
Metabolic Clearance Rate
Middle Aged
Phenotype
Polymorphism, Genetic

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