Article
Nonglutamate pore residues in ion selection and conduction in voltage-gated Ca2+ channels.
Biophysical journal - 1 Nov 1999
Williamson A V, Sather W A
Abstract excerpt
High-affinity, intrapore binding of Ca(2+) over competing ions is the essential feature in the ion selectivity mechanism of voltage-gated Ca(2+) channels. At the same time, several million Ca(2+) ions can travel each second through the pore of a single open Ca(2+) channel. How such high Ca(2+) flux is achieved in the face of tight Ca(2+) binding is a current area of inquiry, particularly from a structural point...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.