Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Feedback control of mitosis in budding yeast.

Cell - 9 Aug 1991

Li R, Murray A W

Abstract excerpt

We have investigated the feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. We isolated budding yeast mutants sensitive to the anti-microtubule drug benomyl. Mitotic arrest-deficient (mad) mutants are the subclass of benomyl-sensitive mutants in which...

Topics

Amino Acid Sequence
Base Sequence
Benomyl
Calcium-Binding Proteins
Carrier Proteins
Cell Cycle
Cell Cycle Proteins
Cell Nucleus
Chromosomes, Fungal
Cloning, Molecular
Cytoskeleton
DNA Mutational Analysis
DNA, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Feedback

Fungal Proteins

Genes, Fungal

Mad2 Proteins

Microtubules

Source

Identifiers

PMID: 1651172
DOI: 10.1016/0092-8674(81)90015-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1651172-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Feedback control of mitosis in budding yeast.PMID 1651172Read ↗

New insights into the regulation of anaphase by mitotic cyclins in budding yeast.Semantic proximity Read ↗

Two complexes of spindle checkpoint proteins containing Cdc20 and Mad2 assemble during mitosis independently of the kinetochore in Saccharomyces cerevisiae.Semantic proximity Read ↗

The mitotic feedback control gene MAD2 encodes the alpha-subunit of a prenyltransferase.Semantic proximity Read ↗

Budding yeast Cdc20: a target of the spindle checkpoint.Semantic proximity Read ↗

Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast.Semantic proximity Read ↗

Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis.Semantic proximity Read ↗

Abnormal kinetochore structure activates the spindle assembly checkpoint in budding yeast.Semantic proximity Read ↗

Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication.Semantic proximity Read ↗

Dbf2 is essential for cytokinesis and correct mitotic spindle formation in Candida albicans.Semantic proximity Read ↗

The Bub2-dependent mitotic pathway in yeast acts every cell cycle and regulates cytokinesis.Semantic proximity Read ↗

Novel mad2 alleles isolated in a Schizosaccharomyces pombe gamma-tubulin mutant are defective in metaphase arrest activity, but remain functional for chromosome stability in unperturbed mitosis.Semantic proximity Read ↗

Mad2-independent spindle assembly checkpoint activation and controlled metaphase-anaphase transition in Drosophila S2 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.