Article
The abnormal p53 proteins expressed in CML cell lines are non-functional.
Leukemia - 1 Nov 1993
Bi S, Lanza F, Goldman J M
Abstract excerpt
Inactivation of the tumor suppressor function of the p53 gene is found in association with 20-40% cases of chronic myeloid leukemia (CML) in blast crisis. A common mechanism of p53 inactivation in CML is by complete deletion of one p53 allele in association with a point mutation which produces a mutant p53 protein on the remaining allele. Whether the mutant p53 protein, which is generally expressed at an elevated...
Topics
- Base Sequence
- Blast Crisis
- Cell Division
- Cell Survival
- Gene Expression Regulation, Leukemic
- Genes, p53
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Molecular Sequence Data
- Mutation
- Oligonucleotides, Antisense