Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The abnormal p53 proteins expressed in CML cell lines are non-functional.

Leukemia - 1 Nov 1993

Bi S, Lanza F, Goldman J M

Abstract excerpt

Inactivation of the tumor suppressor function of the p53 gene is found in association with 20-40% cases of chronic myeloid leukemia (CML) in blast crisis. A common mechanism of p53 inactivation in CML is by complete deletion of one p53 allele in association with a point mutation which produces a mutant p53 protein on the remaining allele. Whether the mutant p53 protein, which is generally expressed at an elevated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Division
Share to Cell Survival

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, p53

Share to Molecular Sequence Data

Share to Mutation

Share to Tumor Cells, Cultured

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 8231251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The abnormal p53 proteins expressed in CML cell lines are non-functional.PMID 8231251Read ↗

Retroviral transduction of Philadelphia-positive chronic myeloid leukemia cells with a human mutant p53 cDNA and its effect on in vitro proliferation.Semantic proximity Read ↗

A splicing mutation accounts for the lack of p53 gene expression in a CML blast crisis cell line: a novel mechanism of p53 gene inactivation.Semantic proximity Read ↗

Genetic alterations in the p53 gene in the blast crisis of chronic myelogenous leukemia: analysis by polymerase chain reaction based techniques.Semantic proximity Read ↗

Mutation of the p53 gene in human acute myelogenous leukemia.Semantic proximity Read ↗

Molecular alterations in theTP53 gene of peripheral blood cells of patients with chronic myeloid leukemiaSemantic proximity Read ↗

Mutation of the p53 gene in human acute myelogenous leukemiaSemantic proximity Read ↗

Role of p53 in leukemogenesis of chronic myeloid leukemia.Semantic proximity Read ↗

Acquired loss of p53 induces blastic transformation in p210bcr/abl-expressing hematopoietic cells: a transgenic study for blast crisis of human CMLSemantic proximity Read ↗

Frequent mutations in the p53 gene in human myeloid leukemia cell linesSemantic proximity Read ↗

Frequent mutations in the p53 gene in human myeloid leukemia cell lines.Semantic proximity Read ↗

Mutational inactivation of the p53 gene in the human erythroid leukemic K562 cell line.Semantic proximity Read ↗

[Mutations of the p53 gene in hematologic neoplasms].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.