Vaccinia virus nucleoside triphosphate phosphohydrolase I controls early and late gene expression by regulating the rate of transcription.

doi:10.1128/JVI.67.12.7561-7572.1993

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Article

Vaccinia virus nucleoside triphosphate phosphohydrolase I controls early and late gene expression by regulating the rate of transcription.

Journal of virology - 1 Dec 1993

Diaz-Guerra M, Esteban M

Abstract excerpt

We have carried out a detailed analysis of viral mRNAs and proteins produced in cultured cells infected with a temperature-sensitive vaccinia virus mutant (ts36) containing a modified nucleoside triphosphate phosphohydrolase I (NPH-I), a nucleic acid-dependent ATPase. Using a recombinant virus (ts36LUC) which expresses the luciferase marker, we showed in seven different cell lines that early expression of the...

Topics

Amino Acid Sequence
Animals
Cell Line
Gene Expression Regulation, Viral
Genes, Reporter
Hot Temperature
Humans
Luciferases
Molecular Sequence Data
Mutation
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pyrophosphatases

RNA, Messenger

Sequence Homology, Amino Acid

Time Factors

Transcription, Genetic

Vaccinia virus

Virion

Source

Open in PubMed Open full text

Identifiers

PMID: 8230476
DOI: 10.1128/JVI.67.12.7561-7572.1993
PMCID: PMC238223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8230476-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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