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Article

Vaccinia virus nucleoside triphosphate phosphohydrolase I controls early and late gene expression by regulating the rate of transcription.

Journal of virology - 1 Dec 1993

Diaz-Guerra M, Esteban M

Abstract excerpt

We have carried out a detailed analysis of viral mRNAs and proteins produced in cultured cells infected with a temperature-sensitive vaccinia virus mutant (ts36) containing a modified nucleoside triphosphate phosphohydrolase I (NPH-I), a nucleic acid-dependent ATPase. Using a recombinant virus (ts36LUC) which expresses the luciferase marker, we showed in seven different cell lines that early expression of the...

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Identifiers

PMID: 8230476
DOI: 10.1128/JVI.67.12.7561-7572.1993
PMCID: PMC238223

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