The nucleoside triphosphatase and helicase activities of vaccinia virus NPH-II are essential for virus replication.

doi:10.1128/JVI.72.6.4729-4736.1998

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Article

The nucleoside triphosphatase and helicase activities of vaccinia virus NPH-II are essential for virus replication.

Journal of virology - 1 Jun 1998

Gross C H, Shuman S

Abstract excerpt

Vaccinia virus NPH-II is the prototypal RNA helicase of the DExH box protein family, which is defined by six shared sequence motifs. The contributions of conserved amino acids in motifs I (TGVGKTSQ), Ia (PRI), II (DExHE), and III (TAT) to enzyme activity were assessed by alanine scanning. NPH-II-...

Topics

Acid Anhydride Hydrolases
Amino Acid Sequence
Animals
Binding Sites
Cell Line
Molecular Sequence Data
Mutation
Nucleoside-Triphosphatase
Protein Binding
RNA Helicases
RNA Nucleotidyltransferases
RNA, Viral
Vaccinia virus
Virus Replication
Zinc Fingers

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