Rescue of an influenza A virus wild-type PB2 gene and a mutant derivative bearing a site-specific temperature-sensitive and attenuating mutation.

doi:10.1128/JVI.67.12.7223-7228.1993

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Article

Rescue of an influenza A virus wild-type PB2 gene and a mutant derivative bearing a site-specific temperature-sensitive and attenuating mutation.

Journal of virology - 1 Dec 1993

Subbarao E K, Kawaoka Y, Murphy B R

Abstract excerpt

Live attenuated influenza A virus vaccines are currently produced by the transfer of attenuating genes from a donor virus to new epidemic variants of influenza A virus, with the selection of reassortant viruses that possess the protective antigens (i.e., the two surface glycoproteins) of the epidemic virus and the attenuating genes from the donor virus. The previously studied attenuated donor viruses were...

Topics

Animals
Antibodies, Viral
Base Sequence
Cricetinae
Genes, Viral
Immunization
Influenza A virus
Molecular Sequence Data
Mutation
RNA-Dependent RNA Polymerase
Recombination, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Respiratory System

Transfection

Vaccines, Attenuated

Vaccines, Synthetic

Viral Proteins

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 8230444
DOI: 10.1128/JVI.67.12.7223-7228.1993
PMCID: PMC238184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8230444-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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