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Replication-incompetent influenza A viruses that stably express a foreign gene

1 Sept 2011

Abstract excerpt

A biologically contained influenza A virus that stably expresses a foreign gene can be effectively traced, used to generate a novel multivalent vaccine and have its replication easily assessed, all while satisfying safety concerns regarding pathogenicity or reversion. This study generated a PB2-knockout (PB2-KO) influenza virus that harboured the GFP reporter gene in the coding region of its PB2 viral RNA (vRNA)....

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PMID: 21880840
DOI: 10.1099/vir.0.037648-0

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