Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A viruses.

PloS one - 1 Jan 2013

Ngai Karry L K, Chan Martin C W, Chan Paul K S

Abstract excerpt

Avian influenza viruses pose a serious pandemic threat to humans. Better knowledge on cross-species adaptation is important. This study examined the replication and transcription efficiency of ribonucleoprotein complexes reconstituted by plasmid co-transfection between H5N1, H1N1pdm09 and H3N2 influenza A viruses, and to identify mutations in the RNA polymerase subunit that affect human adaptation. Viral RNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Influenza A virus
Share to Influenza A Virus, H1N1 Subtype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Influenza A Virus, H3N2 Subtype

Share to Influenza A Virus, H5N1 Subtype

Share to Pandemics

Share to Ribonucleoproteins

Share to RNA-Dependent RNA Polymerase

Share to Viral Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23750226
DOI: 10.1371/journal.pone.0065038
PMCID: PMC3672204

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replication and transcription activities of ribonucleoprotein complexes reconstituted from avian H5N1, H1N1pdm09 and H3N2 influenza A viruses.PMID 23750226Read ↗

Full factorial analysis of mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation.Semantic proximity Read ↗

Prevailing PA Mutation K356R in Avian Influenza H9N2 Virus Increases Mammalian Replication and PathogenicitySemantic proximity Read ↗

The PB1 gene from H9N2 avian influenza virus showed high compatibility and increased mutation rate after reassorting with a human H1N1 influenza virusSemantic proximity Read ↗

The PB1 Gene from H9N2 Avian Influenza Virus Showed High Compatibility and Increased Mutation Rate after Reassorting with a Human H1N1 Influenza VirusSemantic proximity Read ↗

Effect of pandemic influenza A virus PB1 genes of avian origin on viral RNA polymerase activity and pathogenicitySemantic proximity Read ↗

PB2 Residue 271 Plays a Key Role in Enhanced Polymerase Activity of Influenza A Viruses in Mammalian Host CellsSemantic proximity Read ↗

Enhanced genome replication activity of pandemic H1N1 influenza A virus through PA mutations.Semantic proximity Read ↗

Identification of Influenza A Virus PB2 Residues Involved in Enhanced Polymerase Activity and Virus Growth in Mammalian Cells at Low TemperaturesSemantic proximity Read ↗

Genomic Signatures for Avian H7N9 Viruses Adapting to Humans.Semantic proximity Read ↗

The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replicationSemantic proximity Read ↗

PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza virusesSemantic proximity Read ↗

Biochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complex.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.