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Article

Mutations to PB2 and NP proteins of an avian influenza virus combine to confer efficient growth in primary human respiratory cells.

Journal of virology - 1 Nov 2014

Danzy Shamika, Studdard Lydia R, Manicassamy Balaji, Solorzano Alicia, Marshall Nicolle, García-Sastre Adolfo, Steel John, Lowen Anice C

Abstract excerpt

UNLABELLED: Influenza pandemics occur when influenza A viruses (IAV) adapted to other host species enter humans and spread through the population. Pandemics are relatively rare due to host restriction of IAV: strains adapted to nonhuman species do not readily infect, replicate in, or transmit among humans. IAV can overcome host restriction through reassortment or adaptive evolution, and these are mechanisms by...

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Identifiers

PMID: 25210184
DOI: 10.1128/JVI.01093-14
PMCID: PMC4249088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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