Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct contact with herpes simplex virus-infected cells results in inhibition of lymphokine-activated killer cells because of cell-to-cell spread of virus.

The Journal of infectious diseases - 1 Nov 1993

York I A, Johnson D C

Abstract excerpt

Natural killer (NK) and lymphokine-activated killer (LAK) cells are disarmed after contact with herpes simplex virus (HSV)-infected cells. Cells infected with HSV-1 mutants that lack glycoproteins essential for viral entry into cells (gB, gD, gK, gH, and gL) did not inhibit LAK cells; cells infected with HSV-1 mutants that lack glycoproteins not required for virus entry into cells (gE, gI, gG, and gJ) inhibited...

Topics

Antigens, Viral
Cells, Cultured
Cytopathogenic Effect, Viral
Fibroblasts
Glycoproteins
Herpesvirus 1, Human
Humans
Immunity, Cellular
Killer Cells, Lymphokine-Activated
Lymphocyte Subsets

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Virus Replication

Source

Identifiers

PMID: 8228345
DOI: 10.1093/infdis/168.5.1127

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8228345-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct contact with herpes simplex virus-infected cells results in inhibition of lymphokine-activated killer cells because of cell-to-cell spread of virus.PMID 8228345Read ↗

Infection and inhibition of human cytotoxic T lymphocytes by herpes simplex virus.Semantic proximity Read ↗

Individual NK cell clones lyse both tumor cell targets and herpes simplex virus-infected fibroblasts in the absence of interferon.Semantic proximity Read ↗

In vivo immune evasion mediated by the herpes simplex virus type 1 immunoglobulin G Fc receptor.Semantic proximity Read ↗

Human CD8+ CTL recognition and in vitro lysis of herpes simplex virus-infected cells by a non-MHC restricted mechanism.Semantic proximity Read ↗

Molecular determinants of acute single-cell lysis by human immunodeficiency virus type 1.Semantic proximity Read ↗

Recognition and destruction of virus-infected cells by human gamma delta CTL.Semantic proximity Read ↗

Herpes Simplex Inhibits the Capacity of Lymphoblastoid B Cell Lines to Stimulate CD4+ T CellsSemantic proximity Read ↗

Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity.Semantic proximity Read ↗

Importance of Membrane Fusion Mediated by Human Immunodeficiency Virus Envelope Glycoproteins for Lysis of Primary CD4-Positive T CellsSemantic proximity Read ↗

Herpes simplex virus (HSV) glycoproteins B and K inhibit cell fusion induced by HSV syncytial mutants.Semantic proximity Read ↗

Glycoprotein D of herpes simplex virus encodes a domain which precludes penetration of cells expressing the glycoprotein by superinfecting herpes simplex virus.Semantic proximity Read ↗

Human herpes simplex virus (HSV)-specific CD8+ CTL clones recognize HSV-2-infected fibroblasts after treatment with IFN-gamma or when virion host shutoff functions are disabled.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.