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Article

Single amino acid substitutions in gD of herpes simplex virus 1 confer resistance to gD-mediated interference and cause cell-type-dependent alterations in infectivity.

Virology - 15 Feb 1994

Dean H J, Terhune S S, Shieh M T, Susmarski N, Spear P G

Abstract excerpt

Previous studies have shown that cell-associated herpes simplex virus (HSV) glycoprotein gD can interfere with infection of the cells by HSV and other alphaherpesviruses and that HSV mutants resistant to this gD-mediated interference can be isolated. Here we report that HSV mutants selected for resistance to gD-mediated interference are altered in specific infectivity for cells that do not express gD. Two...

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Identifiers

PMID: 8116256
DOI: 10.1006/viro.1994.1098

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