Recognition and destruction of virus-infected cells by human gamma delta CTL.

Abstract excerpt

We examined the response of human gamma delta T cells to herpes simplex virus (HSV). PBMC from HSV seropositive individuals were stimulated with autologous HSV-infected PHA blasts. There was a 4- to 28-fold expansion of gamma delta T cells that were > 95% positive for TCR variable region genes V gamma 2 paired with V delta 2 (V gamma 2V delta 2 T cells). PBMC from these cultures lysed Daudi cells and...

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