Human herpes simplex virus (HSV)-specific CD8+ CTL clones recognize HSV-2-infected fibroblasts after treatment with IFN-gamma or when virion host shutoff functions are disabled.

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Article

Human herpes simplex virus (HSV)-specific CD8+ CTL clones recognize HSV-2-infected fibroblasts after treatment with IFN-gamma or when virion host shutoff functions are disabled.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 1996

Tigges M A, Leng S, Johnson D C, Burke R L

Abstract excerpt

Herpes simplex virus (HSV)-specific CD8+ CTL cloned from individuals infected with HSV-2 efficiently lyse HSV-infected EBV-transformed B lymphoblastoid cells; however, these same CTL fail to lyse infected dermal fibroblasts. By 3 h after infection (early), class I MHC expression is reduced to les...

Topics

Antigen Presentation
B-Lymphocytes
Cell Line, Transformed
Cell Transformation, Viral
Clone Cells
Cytotoxicity, Immunologic
Drug Synergism
Epitopes
Fibroblasts
Herpesvirus 2, Human
Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Immediate-Early Proteins

Immunity, Innate

Interferon-gamma

Mutation

Ribonucleases

T-Lymphocytes, Cytotoxic

Source

Open in PubMed

Identifiers

PMID: 8621929

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8621929-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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