Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin.

Abstract excerpt

Transfection of E- and P-cadherin cDNA has been carried out in murine spindle carcinoma cells previously shown to be deficient in both cadherins (Navarro et al., J. Cell Biol. 115, 517-533, 1991). High levels of expression of E- or P-cadherin do not significantly affect the fibroblastic morpholog...

Topics

• Animals
• Cadherins
• Carcinoma
• Cell Adhesion
• Cytoskeletal Proteins
• Desmoplakins
• Gene Expression
• Mice
• Phenotype
• Trans-Activators
• Transfection
• Tumor Cells, Cultured