Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

L-CAM expression induces fibroblast-epidermoid transition in squamous carcinoma cells and down-regulates the endogenous N-cadherin.

Journal of cell science - 1 Apr 1998

Li Z, Gallin W J, Lauzon G, Pasdar M

Abstract excerpt

SCC9 cells, derived from a squamous carcinoma of the tongue, were shown to lack E-cadherin but express alpha- and beta-catenins and N-cadherin. These cells also lack plakoglobin expression, do not assemble desmosomes and exhibit the typical morphology and growth properties of transformed cells. The N-cadherin expressed in SCC9 cells has properties similar to other classical cadherins, including interactions with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Cell Division
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Macromolecular Substances

Share to Phenotype

Share to Trans-Activators

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 9490644
DOI: 10.1242/jcs.111.7.1005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

L-CAM expression induces fibroblast-epidermoid transition in squamous carcinoma cells and down-regulates the endogenous N-cadherin.PMID 9490644Read ↗

Plakoglobin induces desmosome formation and epidermoid phenotype in N-cadherin-expressing squamous carcinoma cells deficient in plakoglobin and E-cadherin.Semantic proximity Read ↗

Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion.Semantic proximity Read ↗

T-cadherin loss induces an invasive phenotype in human keratinocytes and squamous cell carcinoma (SCC) cells in vitro and is associated with malignant transformation of cutaneous SCC in vivo.Semantic proximity Read ↗

Down-regulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to matrix metalloproteinase-9 gelatinase expression.Semantic proximity Read ↗

Roles of E- and P-cadherin in the human skinSemantic proximity Read ↗

Suppression of E-cadherin function drives the early stages of Ras-induced squamous cell carcinoma through upregulation of FAK and Src.Semantic proximity Read ↗

Tumour-associated E-cadherin mutations alter cellular morphology, decrease cellular adhesion and increase cellular motility.Semantic proximity Read ↗

Epidermal growth factor receptor inhibition promotes desmosome assembly and strengthens intercellular adhesion in squamous cell carcinoma cells.Semantic proximity Read ↗

Loss of intercellular adhesion activates a transition from low- to high-grade human squamous cell carcinoma.Semantic proximity Read ↗

Plakoglobin Regulates the Expression of the Anti-apoptotic Protein BCL-2Semantic proximity Read ↗

Endogenous N-cadherin in a subpopulation of MDCK cells: distribution and catenin complex composition.Semantic proximity Read ↗

The cytoplasmic domain of N-cadherin modulates MMP‑9 induction in oral squamous carcinoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.