Article
L-CAM expression induces fibroblast-epidermoid transition in squamous carcinoma cells and down-regulates the endogenous N-cadherin.
Journal of cell science - 1 Apr 1998
Li Z, Gallin W J, Lauzon G, Pasdar M
Abstract excerpt
SCC9 cells, derived from a squamous carcinoma of the tongue, were shown to lack E-cadherin but express alpha- and beta-catenins and N-cadherin. These cells also lack plakoglobin expression, do not assemble desmosomes and exhibit the typical morphology and growth properties of transformed cells. T...
Topics
- Cadherins
- Carcinoma, Squamous Cell
- Cell Division
- Cell Transformation, Neoplastic
- Cytoskeletal Proteins
- Down-Regulation
- Epidermal Cells
- Epidermis
- Fibroblasts
- Humans
- Macromolecular Substances
- Phenotype
- Tongue Neoplasms
- Trans-Activators
- Tumor Cells, Cultured
- alpha Catenin
- beta Catenin