Article
Tobacco and cancer: epidemiology and the laboratory.
Environmental health perspectives - 1 Feb 1995
Vineis P, Caporaso N
Abstract excerpt
Tobacco smoke contains many mutagenic and carcinogenic chemicals. Both whole tobacco smoke and extracts induce tumors in experimental animals. Work with carcinogen-macromolecule adducts provided evidence for the action of specific chemicals. Molecular epidemiology studies suggested that point mutations in tumor-suppressor genes (e.g., p53) and oncogenes (e.g., ras) may be specific both for the type of tumor and...
Topics
- Confounding Factors, Epidemiologic
- Environmental Exposure
- Genetic Predisposition to Disease
- Humans
- Lung Neoplasms
- Molecular Epidemiology
- Point Mutation
- Smoking
- Urinary Bladder Neoplasms