Article
Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans.
Pharmacogenetics - 1 Jan 1995
Bartsch H, Rojas M, Alexandrov K, Camus A M, Castegnaro M, Malaveille C, Anttila S, Hirvonen K, Husgafvel-Pursiainen K, Hietanen E
Abstract excerpt
A case-control study on lung cancer patients demonstrated the pronounced effect of tobacco smoke on pulmonary carcinogen metabolism and suggested the existence of a metabolic phenotype at higher risk for tobacco-associated lung cancer. Lung cancer patients who were recent smokers showed in their lungs (i) significantly induced CYP1A1-related enzyme activity vs smoking non-lung cancer patients; (ii) increased...
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