Article
Metabolic polymorphism affecting DNA binding and excretion of carcinogens in humans.
Pharmacogenetics - 1 Jan 1995
Bartsch H, Rojas M, Alexandrov K, Camus A M, Castegnaro M, Malaveille C, Anttila S, Hirvonen K, Husgafvel-Pursiainen K, Hietanen E
Abstract excerpt
A case-control study on lung cancer patients demonstrated the pronounced effect of tobacco smoke on pulmonary carcinogen metabolism and suggested the existence of a metabolic phenotype at higher risk for tobacco-associated lung cancer. Lung cancer patients who were recent smokers showed in their...
Topics
- Biotransformation
- Carcinogens
- Case-Control Studies
- DNA Adducts
- Genotype
- Humans
- Lung
- Lung Neoplasms
- Mutagens
- Polymorphism, Genetic
- Reference Values
- Regression Analysis
- Risk Factors
- Smoking