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Article

Genetic modifiers of carcinogen DNA adducts in target lung and peripheral blood mononuclear cells.

Carcinogenesis - 1 Dec 2010

Lee Mi-Sun, Su Li, Mark Eugene J, Wain John C, Christiani David C

Abstract excerpt

Measurement of carcinogen DNA adducts in blood has been used as a surrogate for the target lung tissue. We aimed to examine whether genetic polymorphisms in several metabolic pathway genes modify the relation between DNA adducts in target lung and blood. One hundred and thirty-five early-stage lung cancer patients from the Massachusetts General Hospital were studied. DNA adducts were measured by the...

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Share to Carcinogens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukocytes, Mononuclear

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

Source

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Identifiers

PMID: 20935060
DOI: 10.1093/carcin/bgq208
PMCID: PMC2994283

Genes

ERCC1
ERCC2
MTHFR
NAT2
XRCC1
NQO1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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