Article
Carcinogen metabolism and DNA adducts in human lung tissues as affected by tobacco smoking or metabolic phenotype: a case-control study on lung cancer patients.
Mutation research - 1 Jan 2000
Bartsch H, Petruzzelli S, De Flora S, Hietanen E, Camus A M, Castegnaro M, Geneste O, Camoirano A, Saracci R, Giuntini C
Abstract excerpt
Individual variations in activity of pulmonary enzymes that metabolize tobacco-derived carcinogens may affect an individual's cancer risk from cigarette smoking. To investigate whether some of these enzymes (e.g., cytochrome P450IA-related) can serve as markers for carcinogen-induced DNA damage accumulating in the lungs of smokers, non-tumorous lung tissue specimens were taken during surgery from middle-aged men...
Topics
- Adult
- Aryl Hydrocarbon Hydroxylases
- Carcinogens
- Case-Control Studies
- DNA Damage
- Enzyme Activation
- Epoxide Hydrolases
- Humans
- Lipid Peroxidation
- Lung